Flazol (500mg/100ml) 1 Infusion/Injection

Metronidazole 500MG, when administered parenterally, exerts its therapeutic effects primarily through its active metabolites. These metabolites interfere with the DNA structure and function of susceptible anaerobic bacteria and certain protozoa. The mechanism involves the reduction of the nitro group of metronidazole within the organism, generating reactive intermediates that bind to DNA and disrupt its helical structure. This disruption inhibits nucleic acid synthesis, ultimately leading to the death of the targeted microorganisms. Specifically, metronidazole impairs DNA synthesis by inhibiting bacterial enzyme systems, particularly affecting DNA helicase, causing a loss of DNA helical structure and function. This action is selective for anaerobic bacteria and protozoa due to their reduced metabolic environment, which facilitates the activation of metronidazole and the production of cytotoxic effects.

Antiprotozoal/Antibacterial (nitroimidazole derivative)

Injection

The following are the uses of Metronidazole 500MG Injection:

• Used for treating abdominal infections like peritonitis and intra-abdominal sepsis.
• Used for managing brain infections such as meningitis and encephalitis.
• Used for controlling skin and soft tissue infections, including cellulitis and abscesses.
• Used for addressing bone and joint infections, particularly in cases of osteomyelitis.
• Used for managing pelvic inflammatory disease and other genital tract infections.
• Used for treating severe anaerobic bacterial infections.
• Used for controlling certain parasitic infections, including Giardia and Trichomonas.
• Used for adjunct therapy in specific surgical procedures to prevent infection.

This medicine is available in the form of tablets, gel, vaginal gel, cream, or suspension. Follow these dosage instructions carefully:

• Use the medicine as per your doctor’s recommendation.
• The dosage is dependent on the age, condition, and severity.

In the case of an overdose of Metronidazole 500MG Injection, individuals may experience symptoms such as nausea, vomiting, dizziness, and a general feeling of discomfort. It is important to seek medical advice promptly if an overdose is suspected. The healthcare provider may recommend supportive measures such as monitoring vital signs, providing intravenous fluids, and ensuring the patient’s comfort. Prompt recognition and appropriate medical intervention are crucial in managing potential complications associated with overdoses of this medication.

In the case of a missed dose of Metronidazole 500MG Injection, it is important to take the missed dose as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one, as this may increase the risk of side effects. If you miss multiple doses, contact your healthcare provider for guidance, especially if you are experiencing symptoms or if the medication is for a serious infection. It is advisable to set reminders or alarms to help you remember to take your medication on time.

To administer Metronidazole 500MG Injection, prepare the injection site by cleaning it with an alcohol swab, insert the needle at a 90-degree angle, and slowly inject the entire contents of the vial intramuscularly or intravenously as directed by your healthcare professional.

Here are the circumstances under which Metronidazole 500MG Injection should not be administered:

• Must not be used in patients with a known allergy to Metronidazole or other nitroimidazole derivatives.
• Not suitable for individuals with a history of blood disorders or severe liver disease.
• Contraindicated in patients with severe kidney disease or those on dialysis.
• Should not be used during the first trimester of pregnancy or while breastfeeding.
• Avoid in patients with a history of seizures or neurological disorders.
• Not recommended for individuals with a history of severe gastrointestinal diseases.