Gabapentin (Neurontin)

Gabapentin, a 100mg capsule, acts through a unique mechanism by binding to the α2δ-1 subunit of voltage-gated calcium channels in the central nervous system. This binding interaction leads to a reduction in calcium influx into neurons, which subsequently decreases the release of excitatory neurotransmitters, such as glutamate and norepinephrine. By modulating calcium channel function, gabapentin helps to stabilize neuronal hyperexcitability, thereby exerting its therapeutic effects. This mechanism is believed to contribute to the medication’s effectiveness in managing certain types of neuropathic pain and seizure disorders.